Senior Associate Scientist, Cell Pharmacology @ Pfizer

Job Information

Job Description:

How You Will Achieve It:

Design, plan, and execute studies to explore the mechanism of action of novel drug targets and understand related biology and biomarker responses.
Develop and validate relevant assay systems to screen and characterize small molecules in medium and high-throughput formats.
Design, execute, analyze, and interpret screening data.
Execute routine screening of small molecule drug candidates.
Results and methodologies will be clearly communicated to teams and appropriately documented in laboratory notebooks.
Keep current with appropriate biology and technical literature and contribute new ideas to advance project work.
Contribute to a culture that prioritizes scientific discovery, pursues excellence, and encourages growth.

Qualifications:

Must Have

BS in the biological sciences with 2-5 years of relevant laboratory experience OR Master’s Degree in biological sciences with 0 years of experience
Extensive cell culture experience
Experience in cellular and molecular biology techniques such as western blotting, qPCR, CRISPR-Cas9 or si/shRNA, immunofluorescence, immunoprecipitation, cloning/plasmid engineering, etc.
Has demonstrated success in biochemical and cellular assay design and development such as Nanoluciferase, ELISA, thermo-shift, CETSA, Alpha-Screen, HTRF, etc.
Ability to work independently and design experiments that test complex hypotheses.
Attention to detail, and ability to multi-task/ prioritize and manage timing of daily activities.
Effective oral and written communication skills.
Ability to work well as part of an interdisciplinary team.
Fluency in basic data analysis software such as GraphPad, Excel, Activity Base, etc.

Nice To Have:

Pharmaceutical industry experience
Experience in generation and/or interpretation of multi-omic datasets, such as RNAseq, ChIPseq, proteomics, or functional genomic screens.
Preference for candidates with expertise in oncogenic signaling, cell cycle regulation, and/or epigenetic/transcriptional regulation.

PHYSICAL/MENTAL REQUIREMENTS

Basic job will require both work at the lab bench and analysis time at the computer.
Job will require both work at the lab bench and analysis time at the computer.
Should be comfortable standing in lab for extended periods. Basic analysis skills required, i.e. Excel, GraphPad Prism, etc.

Benefits:
Experience Level: Mid-Senior
Work From: Onsite